An atypical myeloproliferative disorder with high thrombotic risk and slow disease progression

Thrombotic disease in the myeloproliferative neoplasms.

Thrombosis is a leading cause of morbidity and mortality in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), particularly polycythemia vera and essential thrombocythemia. Mechanisms involved in the pathogenesis of the acquired thrombophilic state associated with these diseases include abnormalities of MPN clone-derived blood cells, which display prothrombotic ...

Defining the Thrombotic Risk in Patients with Myeloproliferative Neoplasms

Polycythemia vera (PV) and essential thrombocythemia (ET) are two Philadelphia-negative myeloproliferative neoplasms (MPN) associated with an acquired mutation in the JAK2 tyrosine kinase gene. There is a rare incidence of progression to myelofibrosis and myeloid metaplasia in both disorders, which may or may not precede transformation to acute myeloid leukemia, but thrombosis is the main cause...

Review Series CANCER-ASSOCIATED THROMBOTIC DISEASE Myeloproliferative neoplasms and thrombosis

Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are chronic myeloproliferative neoplasms (MPN) characterized by clonal expansion of an abnormal hematopoietic stem/progenitor cell. Their natural history is marked by thrombohemorrhagic complications and a propensity to transform into myelofibrosis and acute leukemia. The understanding of the MPN pathophysio...

Hemorrhagic and thrombotic complications in patients with myeloproliferative diseases.

OBJECTIVE To correlate the incidence of hemorrhage and thrombosis to bleeding time (BT) and platelet aggregation in 27 consecutive patients with myeloproliferative diseases (MPD). DESIGN Retrospective study. SETTING Public tertiary referral center. PATIENTS Eighteen patients with chronic myelogenous leukemia (CML), 5 with polycytemia vera (PV), 2 with essential thrombocytemia (ET) and 2 w...

Predictive Value of Atypical Thrombotic Episodes for the Subsequent Verification Ph- Negative Myeloproliferative Neoplasm